Cancer, its treatment can accelerate the aging process in young patients

Cancer, its treatment can accelerate the aging process in young patients

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Washington: A new study examined the effects of cancer and its treatment on the aging process and found that the expression of genes associated with aging is higher in younger patients after cancer with chemotherapy and in younger cancer survivors Occurs in people.
The findings have been published online in CANCER, a peer-published journal of the American Cancer Society (ACS).
Previous research has shown that a protein called p16INK4a, which slows cell division, is generated at high levels by cells as an individual. Using gene expression for p16INK4a that codes as a marker of age, Andrew Smithman, MD, MSc at the University of North Carolina at Chapel Hills Lineberger Comprehensive Cancer Center, and colleagues circulating immunity in the blood of a young adult Cells examined revealed childhood cancer and cancer in survivors of children and adolescents.
The team first analyzed cells from 60 survivors and compared them to the cells of 29 age individuals with no history of cancer. The expression of genes that code for p16INK4a was higher in control survivors, representing an age acceleration of 25 years. Nine survivors were vulnerable, and had a higher level of articulation than survivors who were not vulnerable, representing an age acceleration of 35 years.
Researchers also found that nine children and adolescents in the study who had a new diagnosis of cancer had higher expression after treatment with chemotherapy than before treatment.
Dr. “High expression of p16INK4a in peripheral blood lymphocytes has been described in adults after chemotherapy, but not in young adult survivors before this study,” said Smithman.
“This study is important because we try to understand the biological mechanisms underlying the manifestations of early aging in this population,” Smithman said.
Dr. Smithman noted that elevated p16INK4a expression as a marker of aging may help identify cancer survivors who are vulnerable and at risk of developing functional disability.
“Additionally, expression of p16INK4a may prove useful as a measure. study Treatments aimed at reducing the early aging effects of cancer treatment, ”he said.


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