Corona virus, bacteria can work together to increase the severity of the disease in some patients: study

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HOUSTON: The severity of Covid-19 in obese and diabetic sufferers can be attributed to the combined effects of novel coronaviruses and bacteria working together in the body’s physical community – the microbiota – in the lungs, according to a new study.
The research, published in the journal E-Life, evaluated the link between obesity and diabetes from Covid-19, and suggested that the interaction between the novel coronavirus and current bacterial conditions could explain why all diseases Why do people with Alzheimer’s disease often need hospitalization and ventilation?
Philip Shearer, co-author of the study, said: “In the light of obesity and type 2 diabetes, there is growing evidence that all of these risk factors are linked to the severity of codeide-19 infection in all ethnic groups, but these risk factors Detailed basic contacts with are mostly unknown. ” From the University of Texas Southwest Medical Center in the United States.
“There is a contradiction that people with obesity and diabetes are generally known to have better lung conditions than others. So, what about Covid 19 that makes this group of people more sensitive? ۔ ”
In the study, scientists reviewed the factors and disease pathways that link obesity and diabetes to the severity of a Code 19 infection.
They found that the mechanism could be roughly divided into two groups – those that are connected to the ACE2 receptor of human cells, and those that provide interactions between Covid-19 and pre-existing bacterial conditions.
The scientists explained that the ACE2 receptor resides on the surface of many cells in the human body, and is involved in regulating blood pressure and the function of blood vessels, and is also used by viruses to enter human cells. ۔
They hypothesized that an increase in the amount of ACE2 in obese or diabetic individuals makes it easier for the virus to enter the cells and increases the viral load – an important factor in determining the severity of the disease.
Alternatively, due to the increased flow of ACE2 in obese people, it is transmitted to the lungs, where the virus can use it, the researchers said.
They believe that the body’s own microbiota may also play a role in increasing the risk of lung disease.
According to scientists, humans carry more than 100 trillion bacteria in their bodies – far more than the number of our own cells.
He said that people suffering from obesity and diabetes are exposed to the spread of bacteria and their substances on the body surface, which results in persistent inflammation in the lower extremities of various tissues.
Scientists are currently trying to figure out how the host bacteria can affect the severity of Covid-19.
He said a possible culprit could be the lipopolysaccharide (LPS) molecule that produces bacteria, which he said could co-exist with other corona viruses to cause respiratory distress in pigs.
The study found that LPS molecules could potentially join forces with code 19 in humans and initiate a series of events that resulted in the transformation of healthy tissue into scarred tissue.
“While all of these possible mechanisms may play a role in the severity of COVD-19, we believe that one of them may play a role, and that it should occur not only in obese and diabetic patients, but also in those at risk. The addition of should be in other groups as well. In Kwid-19, “Sheher explained.
A joint deficiency in ACE2 caused by Code-19, along with obesity or diabetes, can lead to impaired bowel obstruction, which can cause bacteria and their toxins to circulate, the scientists said.
They believe that these bacteria and toxins are working with the virus in the lungs, causing them to cause much more serious injury.
“Our theory is supported by experiments that show that a combination of bacterial and viral infections can cause a ‘cytokine storm’ – a highly inflammatory response – a feature of Code 19.
“In addition, involvement in viral bacterial interactions may explain the increased risk of severe Covid 19 in the elderly, heart disease and some ethnic groups,” he added.

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