Cross-neutral SARS-CoV-2 in vitro antibodies of patients infected with SARS-CoV in 2003: a study

Cross-neutral SARS-CoV-2 in vitro antibodies of patients infected with SARS-CoV in 2003: a study

WASHINGTON: Antibodies in serum samples obtained from patients infected with SARS-CoV during the 2003 outbreak effectively neutralized SARS-Co-2 infection in cultured cells, according to a new study.
The study was published in the journal Science Advances.
The authors also point out that, surprisingly, rats and rabbits were vaccinated against the stork-coyote strain with a receptor-binding domain (RBD) that affects the Himalayan palm outpost, which causes In addition, vaccinated animals have stronger antibody reactions against SARS-CO2. From human stork-coyote stress
The authors suggest that their findings may inform emerging and future strategies for developing a universal vaccine against corona virus. Yuanmi Zhu and colleagues analyzed 20 convulsant serum samples from SARS-CoV-infected patients, including four regions of the SARS-Co-2 spike protein, including S-actodomain (S), S1 subunite, RBD. Cross reactivity has been determined for the obtained protein antigens. , And S2 subunit. While all serum samples reacted strongly with S and S2 proteins, they reacted more strongly with S1 and RBD proteins. A separate test using a single-cycle infection assay determined that the concomitant SARS-CoV sera had both SARS-CoV and SARS-CoV-2 pseudoviruses (which cannot produce viral surface proteins on their own) affecting cells Prevents, although they have stopped the stork. -Q-2 activity less efficiently.
The researchers confirmed their findings in animals and specifically pointed out the ability of RBD to mediate cross-reactivity in mice because RBD is the least secure of the spike protein sites between the two viruses. They found that the anti-RBD serum from SARS-COVI reacted well with SARS COVI 2, indicating that a major antigen in the RBD sites of two major viruses The component is genetically protected.
ذُو hu ال al. Note that although antibody-dependent growth (when binding a virus to certain antibodies actually facilitates its entry into host cells) was not observed, its effect on vaccine development Should be during

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