Diseases of children related to coronovirus are associated with changes in blood cell, the study said

Diseases of children related to coronovirus are associated with changes in blood cell, the study said

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London: A newly described disease occurring in children and associated with the Kovid-19 immune system is associated with significant changes in white blood cells, according to a study that allows doctors to better assess the condition of their young patients and currently May allow predicting their resistance. the treatment.
Pediatric inflammatory multisystem syndrome temporarily associated with SARS-CoV-2 infection (PIMS-TS) is a new disease that shares some features with Kawasaki disease – inflammation of blood vessels mostly children under the age of five. Affects – as well as toxic shock syndrome.
Researchers led by researchers from the University of Birmingham in the UK examined blood samples of children admitted to Birmingham Children’s Hospital during the country’s coronovirus lockdown.
The yet-to-be-reviewed peer-reviewed findings have been published in the preprint platform MedRixive, which describes large changes in monocytes – a type of white blood cell – in patients with PIMS-TS and Kawasaki disease.
“Our study showed that both Kawasaki disease and PIMS-TS are characterized by profound changes in the number of monocytes and their genetic makeup,” said Graham Taylor, co-lead author of the study at the Institute of Immunology and Immunotherapy. University of Birmingham.
“Our results require confirmation in a larger patient cohort, but the changes we observed are likely to be highly relevant – potentially allowing us to predict PIMS-TS and disease resistance of children with Kawasaki disease Gives, as well as identify alternative treatments. Both diseases, “Taylor said.
In the study, researchers recruited nine children with signs of PIMS-TS presented at Birmingham Women’s and Children’s Hospital from April to May 2020.
Seven of them met PIMS-TS, the UK’s Royal College of Pediatrics and Definition of Child Health Case, and SARS-COV-2 antibodies were positive, according to the scientists, while two children met the criteria for the diagnosis of Kawasaki disease , And were SARS-CoV-2 antibody negative.
According to Barney Shollefield, pediatric intensive care consultant at Birmingham Women’s and Children’s Hospital NHS Foundation Trust, “Children admitted to intensive care units globally with PIMS-TS did immediate research to understand this rare but probable life situation the wanted.”
“The University of Birmingham team has conducted an increasingly novel, in-depth analysis to identify potential targets for treatment. The cutting-edge approach used will help future children affected by Kovid-19,” Scofield said.
Scientists identified major changes in the monocyte cells of the immune system in children with both diseases.
Although novel coronoviruses usually cause only mild respiratory infections in children and young adults, in rare cases, they may later develop PIMS-TS – presenting evidence of fever, inflammation, and organ failure, resulting in cardiac arrest. Has dysfunction, hypotension and life-threatening tremors, the study noted.
According to the researchers, PIMS-TS shares clinical features with Kawasaki disease.
He said that if left untreated, the disease can cause inflammation of the heart muscle, and is the leading cause of acquired heart disease in children in developed countries.
Given the recent emergence of PIMS-TS, scientists said that little is known about the immune processes that drive the condition, and whether these are similar or different from Kawasaki’s disease.


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