DNA tests can quickly detect pneumonia in Covid 19 patients, leading to faster treatment: study

DNA tests can quickly detect pneumonia in Covid 19 patients, leading to faster treatment: study

Cambridge / UK: A team of scientists and doctors from the Cambridge University and Cambridge University Hospitals NHS Foundation Trust have developed a DNA test that they claim will identify the second-most common infection in Covid 19. , In which the risk of pneumonia is doubled. On ventilation
For patients with the most severe forms of covid-19, the most common way to keep them alive is through mechanical ventilation, as doctors use anti-inflammatory treatments to treat their swollen lungs. However, these patients are more susceptible to bacterial and fungal infections that they can get while in the hospital, according to research.
A team of scientists and physicians from the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, led by Professor Gordon Dogan, Dr. Wallace Navapurkar, and Dr. Andrew Kone Morris, are working to identify these infections and identify the target early. Has developed a simple CNA test. Antibiotic treatment as needed
The test, developed in collaboration with Public Health England at Edenbrook Hospital, provides doctors with information on the need to start treatment within hours instead of these days, fine-tuning treatment as needed and inappropriate antibiotics. Reduce usage.
The procedure, based on advanced thrombotic DNA testing, is being introduced at Cambridge University Hospital and generally offers a way toward better treatment of the infection. The results are reported in the journal Critical Care.
Patients who require mechanical ventilation are at particular risk of developing secondary pneumonia while receiving intensive care. These infections are often caused by antibiotic-resistant bacteria and are difficult to diagnose and require targeted treatment.
Co-author Dr. Andrew Kone said, “Early in the epidemic we saw that Covid-19 patients were particularly at risk of secondary pneumonia, and began using a rapid diagnostic test that we prepared for a similar situation. What was Morris from the Cambridge Department of Medicine and an intensive care consultant.
It is believed that Covid 19 patients have an increased risk of infection for a number of reasons. Due to the amount of damage to the lungs, these severe cases of Covid-19 spend more time on the ventilator than patients with Covid-19. In addition, the immune system of many of these patients is dysfunctional, where immune cells damage organs, but also impair antimicrobial functions, increasing the risk of infection.
In general, the diagnosis of pneumonia is difficult to confirm, as patients’ bacterial samples need to be cultured and grown in the laboratory, which takes time. The Cambridge test adopts an alternative approach to detecting the DNA of different pathogens, which allows for faster and more accurate testing.
This test uses multiple polymerase chain reaction (PCR) that detects bacterial DNA and can be done in about four hours, meaning the need to wait for the bacteria to grow. do not have.
The test – developed with Dr. Martin Korn, a PCR diagnostic specialist at Cambridge Laboratory in Public Health England – runs multiple PCR reactions in parallel, and can select 52 different pathogens simultaneously. Which often affects the lungs of patients in intensive care. At the same time, it can also test for antibiotic resistance.
“We found that although Covid-19 patients were more likely to have secondary pneumonia, the bacterial infection due to Covid-19 was the same as in ICU patients without Covid-19. This means that Covid-19 patients Standard antibiotic protocols can be applied, “said lead author Melissa Mayes, from the Department of Medicine.
This is one of the first time that the technology has been used in routine clinical practice and is now approved by the hospital. Researchers hope that if such an approach is widely used, patients will benefit.

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