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‘Frustration science’ slows down the hunt for coronovirus drugs

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Washington: The world is struggling for rapid answers and solutions, from a research system not made for haste, to solving the deadly condorium of Kovid-19.
Irony and perhaps tragic, the result: Scientific shortcuts have slowed the understanding of the disease and delayed the ability to detect which drugs help, hurt, or have no effect on them.
As deaths from coronoviruses steadily climb to thousands, tens of thousands of doctors and patients raced to use drugs before they could be proven safe or effective. A group of low-quality studies further tarnished the picture.
“There was an epidemic in front of people and he was not prepared to wait,” said Dr. Derek Angus, head of critical care at the University of Pittsburgh Medical Center. “We made traditional clinical research so slow and cumbersome.”
It was not until mid-June – about six months – when the first evidence came that a drug could improve survival. Researchers in the United Kingdom managed to include one of every six hospitalized Kovid-19 patients in a large study that found a cheap steroid called dexamethasone helps and is widely used There is no known malaria drug.
The study changed practice overnight, even though the results were not published or reviewed by other scientists.
In the United States, a small but rigorous study found a different drug that could reduce recovery time for critically ill patients, but many questions remain about their best use.
Doctors are still reaching for something else that can fight in many ways that harm the virus, stroke, heartburn, blood clots, arthritis, depression, inflammation, AIDS, hepatitis, cancer, arthritis and even That are experimenting with drugs for stem cells and radiation. .
“Everyone is greedy for anything that can work. And that’s how you develop sound medicine, “Dr. Steven Nissen, a researcher at the Cleveland Clinic and a frequent adviser to the US Food and Drug Administration.” Frustration is not a strategy. ”
The us There have been certain studies in which some of them have reduced their own or loosely sponsored work to drug companies.
And politics exacerbated the problem. After being promoted by President Donald Trump, tens of thousands of people tried to eat malaria medicine, saying, “What have you got to lose?” Meanwhile, the country’s top infectious disease specialist, Drs. Anthony Fauci warned, “I like to prove things first.”
For three months, weak studies polarized the idea of ​​hydroxychloroquine until many more reliable people found it ineffective for treatment.


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