How Good Gut Bacteria Helps Reduce Risk of Heart Disease

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New York: Researchers have discovered that one of the best bacteria found in the human intestine has the potential to reduce the risk of heart disease.
The activity of bacteria in the intestines reduces the production of a chemical, which has been linked to the development of clogged arteries, the study has been published in the Journal of Biological Chemistry.
“The organism we studied affects health by preventing a problematic compound from deteriorating,” said Joseph Crazy, a researcher at Ohio State University in the US.
For the findings, the research team traced the behavior of the bacteria to a family of proteins that they suspect could suggest other ways that good gut organisms may contribute to human health.
In short, these microbes compete with bad bacteria for access to similar nutrients in the gut and if good bacteria win, they can prevent health problems that can result in how the body metabolizes food. is.
Much work is ahead, but scientists see the ability to use this microbe acter Eubacterium limosum ‘for medical purposes in the future.
Previous research has already shown that the bacterium is “good” because it calms inflammation in the gut. The chemical associated with arteries that characterize atherosclerosis is called trimethylamine or TMA.
It arises during intestinal germs when certain intestinal microbes – bacteria generally considered harmful to humans – interact with certain nutrients from food.
Among those nutrients is L-carnitine, a chemical compound found in meat and fish that is also used as a nutritional supplement for post-exercise improvement.
The research team found that E. The limosum interacts with L-carnitine in the gut in a different way, and this interaction eliminates the role of L-carnitine in the production of TMA (other nutrients also participate in TMA production in the intestine).
Researchers attribute the beneficial behavior of bacteria to a protein, called MtcB, an enzyme that helps bacteria to grow and survive by cutting specific molecules of compounds. The process is called demethylation, and involves the removal of a methyl group – a carbon atom surrounded by three hydrogen atoms – to change the structure or function of a compound.
“The bacterium does this to its advantage, but it has the negative effect of reducing the toxicity of TMA,” said Crazeneck.

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