‘Key element of strong antibody response to Kovid-19 decode’

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LOS ANGELES: Scientists have discovered a common feature found in many human antibodies that neutralize novel coronaviruses, a discovery that they say could aid successful vaccine development against Kovid-19.
While many vaccine candidates have entered clinical trials, the researchers, including those at the Scripps Research Institute in the US, stated that features of human antibodies that contribute to the most effective immune response against novel coronaviruses – SARS -CoV-2 – Be unclear.
In a study published in the journal Science, they identified about 300 recent human SARS-CoV-2 antibodies, and frequently revealed a gene associated with those most effective against the virus.
Researchers reported that SARS-CoV-2 uses the receptor binding domain (RBD) on its spike protein to bind to the host cell-surface receptor, ACE2 and to infect human cells.
They stated that antibodies that can target RBD and block ACE2 have been highly sought, and a number has been discovered.
In the current study, scientists including Yuan Meng of the Scripps Research Institute assessed a list of 294 such RBD-targeting antibodies.
They found that a gene in the IGHV gene family, called IGHV3-53, is the most commonly used IGHV gene to target RBD of the virus spike protein.
IGHV3-53 antibodies, the researchers said, not only have low mutation rates, but are also more powerful in neutralizing viruses.
By studying the 3D structures of two IGHV3-53 antibodies bound to RBD, the researchers identified characteristics that make them effective and promising for vaccine design.
The study notes that, overall, our structural analysis suggests that IGHV3-53 provides a versatile framework to target the ACE2 binding site in SARS-CoV-2 RBD.
Researchers said the results of the study may facilitate the design of vaccine agents that can help strengthen the antibody response.
“As IGHV3-53 is found at a reasonable frequency in healthy individuals, this particular antibody response can usually be elicited during vaccination,” he wrote in the study.

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