Kovid-19 does not directly cause loss of taste: study

Kovid-19 does not directly cause loss of taste: study

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Washington: Kovid-19 does not directly harm taste bud cells, according to a study which found that taste loss is likely indirectly related to events induced during inflammation due to the disease.
The findings, published in the journal ACS Pharmacology and Translational Science, are in contrast to previous studies that have shown that damage can be directly caused by virus mites.
An increasing number of Kovid-19 patients have reported loss of smell or taste, prompting researchers to add it to the growing list of Kovid-19 symptoms.
Recent research suggests that 20–25 percent of patients now report a loss of taste, according to the team.
“More worryingly, patients are reported to have loss of taste at a later date after exposure to the virus,” said Hongxiang Liu, an associate professor at the University of Georgia in the US.
“This is something we need to monitor carefully,” Liu said.
The study also indicates that taste bud cells are not vulnerable to SARS-CoV-2 infection, as most of them do not express ACE2, a gateway that the virus uses to enter the body.
“This study is not the first to study ACE2 expression in the oral cavity,” Liu said.
“But this is the first time to show, especially in relation to coronovirus and taste bud cell survival, that the play is likely to have other cell death mechanisms,” she said.
Liu and his colleagues wanted to find out if ACE2 was specifically expressed in taste bud cells, as well as when this receptor first emerges on oral tissue cells during embryonic development, the mice were exposed to a model organism. By studying as.
Although the mouse version of ACE2 is not susceptible to SARS-CoV-2, it can still make it clear in studies expressed in mice that when people become infected and lose their sense of taste, That mice and humans share similar expression patterns.
“Mice have a different cellular copy of ACE2, which makes them impermeable to SARS-CoV-2 infection,” Liu said.
“A logical first step was to genetically engineer a model that provides insights into what happens in people, to examine ACE2 receptor expression in wild-type mice,” she said.
By analyzing the data on oral cells of adult mice, the researchers found that ACE2 was rich in cells that give the tongue its rough surface, but cannot be found in most taste bud cells.
This means that the virus does not affect taste loss through direct infection of these cells, he said.
“It is clear from the data, that future designs of therapeutics directed at ACE2 receptors will probably not be effective in treating the loss of taste of patients suffering from Kovid-19,” Liu said.


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