Kovid: IIT-Roorkee to work on antiviral detection. India news

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BENGALURU: A proposal by a team led by Professor Pravindra Kumar at IIT-Roorkee to identify structure-based potential antivirals against SARS-CoV2 triggered the support of Science and Engineering Research Board (SERB) under the Department of Science and Technology Has DST).
The study, which will be funded under intensive research into high priority areas (IRHPA), will search for small molecule inhibitors targeting some of the most important viral replication enzymes.
“These enzymes are viral proteases (papain-like proteases and 3CLproteases), RNA dependent RNA polymerase (nsp12), and methyltransferase or MTS (nsp14). Viral germs, encoded by the genetic material (DNA or RNA) of viral pathogens There are enzymes that catalyze the cleavage of specific peptide bonds in cellular proteins, ”said DST.
DST stated that in the study, a computer-based high throughput virtual screening approach would be used to identify antiviral molecules from various compound libraries that would be experimentally valid for antiviral potential.
Associate Dr from IIT Roorkee. Shali Tomar and Dr. from Indian Veterinary Research Institute (IVRI), Bareilly. Gaurav Sharma will help in the experimental testing and evaluation of the antiviral efficacy of the identified antiviral molecules against SARS-COV-2.
As a preliminary work, investigators have already worked with a high throughput virtual screening approach in silica (performed on a computer) that examines binding affinity of the FDA-approved drugs to target viral protease MPro.
“The hunt for new drugs, including reconstituted drug candidates, is being fueled by an in silico approach, which allows to identify potential antiviral molecules based on computer simulations of their molecular structures. Experimental and This approach is expected to be very fast and accurate in the selection of potential drugs and vaccines for clinical trials, ”said Professor Ashutosh Sharma, Secretary, DST.
DST stated that using a structure-based approach to drug re-purposing, this study would pave the way for identifying molecules that bind to the Mpro active site, and their potential use as antiviral molecules against Kovid-19 Can be done, DST added.

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