Kovid lung damage due to persistence of ‘abnormal cells’, scientists say – Health

Kovid lung damage due to persistence of ‘abnormal cells’, scientists say – Health

Scientists have analyzed organ samples from deceased Kovid-19 patients and found extensive lung damage in most cases due to the persistence of abnormal “fused cells”, an advance that sheds more light on disease progression.

Researchers examined lung, heart, liver and kidney samples of 41 patients, including those at King’s College London in the UK, to examine the behavior of the novel coronovirus SARS-COV-2, which killed Kovid-19 .

In the study, published in the journal EasyMedicine, they revealed the unique features of the virus that could explain why some patients experience symptoms of the disease for months – known as ‘long covids’ – in fatigue and With shortness of breath.

The findings reflect widespread lung damage in most cases, with patients experiencing profound disruption of normal lung structure and respiratory tissue changes in fibrotic material.

According to scientists, about 90 percent of the patients showed additional features that were quite unique compared to other forms of Kovid-19.

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He stated that a broad blood clot had accumulated in the arteries and veins of the lungs, and that many lung cells with many nuclei were abnormally large, resulting in the fusion of different cells into single large cells. Researchers noted that the formation of fused cells – syncytia – is caused by viral spike proteins, which the virus uses to enter the cell. When the protein is present on the surface of cells infected with Kovid-19 virus, the study noted that it stimulates their fusion with other normal lung cells, which may cause inflammation and thrombosis.

Research also showed the long-term persistence of viral genomes in infected cells as well as in respiratory cells and in cells lining the blood vessels. According to the researchers, the presence of these infected cells can cause major structural changes observed in the lungs, which may persist for several weeks or months, and may eventually explain the ‘long covid’.

“The findings suggest that Kovid-19 is not simply a disease caused by the death of virus-infected cells, but is likely to result from prolonged exposure of these abnormal cells inside the lungs,” co-author Mauro Giacca Said study from King’s College London.


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