According to studies reviewed, delirium or mental confusion with fever may be the earliest symptoms of Kovid-19, especially in elderly patients.
Research published in the Journal of Clinical Immunology and Immunotherapy suggests that along with the loss of senses of taste and smell, and headaches that occur in the days before coughing and shortness of breath, some patients are also referred to as delirium. .
As such, with high fever, when the manifestation of this state of confusion should be considered an early marker of the disease, especially in the case of elderly patients.
“Delirium is a state of confusion in which the person feels out of touch with reality, as if they are dreaming,” explained Xavier Coría from Universitat Oberta de Catalunya (UOC) in Spain.
Correa, who carried out the study at the University of Bordeaux in France, said, “We need to be on alert, especially in such an epidemiological situation, because the person presenting some signs of confusion is a sign of infection Could. “
Correa, along with UOC researcher Diego Radollar Ripoll, reviewed published scientific work on the effects of Kovid-19 in relation to the central nervous system, ie the brain.
The review found that there are indications that the novel coronovirus also affects the central nervous system, and produces neurocognitive changes, such as headaches and delirium, as well as mental episodes.
“Key hypotheses that explain how coronovirus SARS-CoV-2 affects the brain point for three possible reasons: hypoxia or neuronal oxygen deficiency, inflammation of brain tissue due to cytokine storms, and the fact that the virus crosses blood Has the ability to do – a barrier to attack the brains directly.
He said that any of these three factors is likely to cause delirium.
Evidence of hypoxia-related brain damage has been seen in autopsy performed on patients who have died of infection, and it has been possible to separate the virus from brain tissue, Correa said.
According to the researchers, delirium, cognitive deficits and behavioral anomalies are most likely the result of systemic inflammation of the limb and hypoxia, which also leads to inflammation in the neuronal tissue and causes damage in areas such as the hippocampus.
They stated that it is associated with cognitive dysfunction and behavioral changes presented by patients with delirium.
(This story is published from a wire agency feed without textual modifications.)
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