Modern Vaccine News: This month the modern coronavirus vaccine enters final stage trials

Modern Vaccine News: This month the modern coronavirus vaccine enters final stage trials

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Washington: American biotech firm Modern said on Tuesday that it will enter the final phase of human trials for its Kovid-19 vaccine on July 27 to test how well it protects people in the real world is.
The announcement had already come as a test result to prove that the vaccine was safe and that triggered antibody production had been published.
The upcoming Phase 3 trial will recruit 30,000 participants in the US, with half of them receiving the vaccine at the 100 microgram dose level, and the other half receiving a placebo.
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The researcher will then track them over two years to determine whether they are protected from infection by the virus. Or, if they are infected, does the vaccine prevent symptoms from developing.
If they do get symptoms, the vaccine can still be considered a success if it prevents severe cases of Kovid-19.
The study should last until October 27, 2022, but preliminary results should be available much earlier.
The announcement was made shortly after the New England Journal of Medicine published results from the first phase of Modern’s vaccine trial, in which the first 45 participants showed the virus to all developed antibodies.
The modern race is considered to be in a leading position in the global race to find the vaccine against coronovirus, which has infected more than 13.2 million people and killed 570,000 people.
But scientists warn that the first vaccines to come on the market may not be the most effective or the safest.
Modern previously published “interim results” from the first stages of its trial, called Phase 1 in May.
The initial results were called “encouraging” by Anthony Fauci, director of the US National Institute of Allergy and Infectious Diseases, a co-development of the vaccine.
But some scientific community said they would preserve the verdict until they saw the full results as peer-reviewed.
According to the paper, 45 participants were divided into three groups to test doses of 25 μg, 100 μg and 250 μg.
He was given a second dose of the same amount 28 days later.
After the first round, antibody levels were found to be higher with higher amounts.
After the second round, participants had higher levels of antibodies than most patients who went on to produce Kovid-19 and their own antibodies.
More than half of the participants experienced mild or moderate side effects, which are considered normal.
Side effects included fatigue, chills, headaches, body aches, and pain at the injection site.
Three participants did not receive their second dose.
They included one man who developed a skin rash on both legs, and two who missed his window because he had Kovid-19 symptoms, but his tests later returned negative.
Amesh Adalja, an infectious disease specialist at Johns Hopkins University, said that it was encouraging that participants developed a high level of advanced antibodies.
He said, however: “You should be limited in how much extra from a phase one clinical trial, because you want to see how it works when a person is exposed to the actual virus.”
The modern vaccine belongs to a new class of vaccine that uses genetic material – in the form of RNA – to trigger the immune response, to encode the information needed for the virus’s spike proteins to grow inside the human body. .
The spike protein is a part of the virus that is used to invade human cells, but the protein itself is relatively harmless.
The advantage of this technique is that it reduces the need for the manufacture of viral proteins in the laboratory, which helps in mass production.
No vaccines based on this platform have previously received regulatory approval.
Preliminary work using this technique by making hosts more, not less, susceptible to infection, David Low, a biomedical science professor at the University of California Riverside, told AFP.
He said, “One of the things we definitely want to focus on is what the long-term effects are, where the immune response … potentially develops an immunological tolerance that would actually be harmful to safety, ” They said.


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