Scientists decode how lungs are severely damaged in severe Kovid-19 using novel imaging techniques

Scientists decode how lungs are severely damaged in severe Kovid-19 using novel imaging techniques

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Berlin: Using a novel technique that enables high resolution imaging of damaged lung tissue, scientists have found changes in the structure of the organ’s blood vessels and air sac due to severe Kovid-19, which new treatment methods May support the development of the disease.
In the study published in the journal eLife, scientists developed a new X-ray technique that enables high resolution and three-dimensional imaging of lung tissue infected with the novel coronovirus SARS-COV-2.
Using the new method, researchers including researchers from the University of Gottingen in Germany noticed significant changes in the blood vessels, inflammation, and the deposition of proteins and dead cells on the walls of the small air sac of the lungs, called alveoli.
He stated that these changes make gas exchange by organ difficult or impossible.
According to scientists, the new imaging approach allows these changes to be visualized for the first time in large tissue volumes without cutting and staining or damaging the tissue.
He stated that it is particularly suitable for tracing small blood vessels and their branches in three dimensions, localizing cells of the immune system present at inflammatory sites and measuring the thickness of alveolar walls.
Due to the three-dimensional reconstruction of lung tissue, the researchers stated that the data could also be used to simulate gas exchange in the organ.
As X-rays penetrate deeper into the tissue, he said scientists can use the method to understand the relationship between microscopic tissue structure and the large function of an organ.
The researchers wrote in the study, “Based on this first proof-of-concept study, we propose multi-scale phase contrast X-ray tomography as a tool to learn the pathophysiology of Kovid-19.”
Scientists believe that the technology will support the development of treatment methods and drugs to prevent or cure severe lung damage in Kovid-19 or to promote recovery.
“It’s only when we can clearly see and understand what’s really going on, that we can develop targeted interventions and drugs,” said Danny Zonig, co-author of the study at the Medical University of Hannover in Germany Huh.


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