Scientists decode how much blood oxygen levels are decreased in Kovid-19 patients

Scientists decode how much blood oxygen levels are decreased in Kovid-19 patients

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New York: Kovid-19 is causing significant dilation of lung blood vessels, contributing to the much lower oxygen levels seen in patients with respiratory failure, according to a new research that provides better treatment to severely affected people Can help to do. disease.
A pilot study of 18 patients published in the American Journal of Respiratory and Critical Care Medicine helps explain how Kovid-19 behaves differently than classic acute respiratory distress syndrome (ARDS) in which lung blood in the inflamed limb The vessels leak.
In ARDS, the study states that leaky blood vessels in the lungs fill the organ with fluid and make it hard, impaired oxygen.
According to scientists, including those at Mount Sinai Hospital in the US, many patients with Kovid-19 pneumonia experience severely low levels of oxygen in the blood that is out of proportion to the amount of lung stiffness.
In the current study, researchers evaluated whether the mechanisms known for low blood oxygen in Kovid-19, or hypoxemia, differ from classical ARDS.
They used a robot probe to perform a “bubble study”, a non-invasive and painless scanning technique using very high-speed sound waves.
Mount Sinai Hospital co-author Alexandra Reynolds said, “The advantage of using this particular system was that automated monitoring allowed providers to assess brain blood flow while reducing the likelihood of exposure to Kovid-19. Granted. ”
During this study, he injected a salt solution with small microbes into the patient’s vein and used a robotic scan device to determine if microbubes appeared in the blood vessels of the brain.
Under normal circumstances, scientists said that these microscopic bubbles would travel to the right side of the heart, enter the blood vessels of the lungs, and could eventually be filtered by the pulmonary capillaries because the diameter of the bubble is larger than the diameter of the small blood vessels in the lungs. .
If microbills are detected in the blood vessels of the brain, it is implied that there is either a hole in the heart, so that the blood can travel from the right side of the heart to the left without going through the lungs, or that the capillaries study. It has been said that there is an abnormal expansion in the lungs, through which microbials pass.
In the pilot study, scientists assessed 18 mechanically ventilated patients with severe Kovid-19 pneumonia using the bubble study method.
According to the researchers, 15 of 18 (83 percent) patients had detachable microbubbles, indicating the presence of abnormally dilated blood vessels in their lungs.
Scientists said the number of microbubbles discovered by the device correlated with the severity of oxygen deficiency indicates that dilatation of blood vessels in the lungs may explain the hypoxemia seen in many patients with Kovid-19.
The study notes that the number of these microbes does not correlate with the severity of low oxygen levels, implying that dilation in lung blood vessels is not a major mechanism in classical ARDS.
“It is becoming clear that the virus wreaks havoc on the pulmonary vessel in many ways,” said Homan Por, senior author at Mount Sinai Hospital.
“This study helps explain the bizarre phenomenon seen in some Kovid-19 patients, known as ‘happy hypoxia’, where oxygen levels are very low, but patients do not show respiratory distress. Give, ”said the poor.
If the findings are confirmed in larger studies, scientists believe that microbiol transit could potentially serve as a marker of disease severity, or a proxy endpoint in clinical trials for Kovid-19 pneumonia Can also happen.
“Future studies that examine the use of pulmonary vascular inhibitors in this patient population may be warranted,” said Poor.


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