Scientists identify antibodies to make pan coronavirus vaccine

Scientists identify antibodies to make pan coronavirus vaccine

New York: Scientists have discovered human antibodies that can neutralize many different corona viruses and pave the way for a pan corona virus vaccine.
These antibodies have been found in some people who have recovered from Covid 19, the University of Washington team said.
The study, published in the journal Science, described research on five human monoclonal antibodies that can react with multiple beta corona viruses.
The team tested some memory B cells from donors who recovered from Covid 19. Memory B cells are white blood cells that recognize and respond to pathogens that have tried to attack the body during a previous encounter.
Of the five promising antibodies they isolated, the scientists decided to focus on one named S2P6. Molecular structure analysis and functional studies show that this human monoclonal antibody has an impressive range: it was able to neutralize three different subspecies of beta corona virus. Scientists observed that this was done by blocking the ability of the virus to fuse with cell membranes.
These antibodies target a structure in the spike protein of these viruses, called the stem helix. The spike protein is important for the ability of the virus to repel host cells.
Stem helix in spike proteins has been preserved during the evolution of specific corona viruses. This means that it is less susceptible to genetic mutations and is similar to various corona viruses, explained Dora Pinto, lead author at the University of Seattle’s School of Medicine in Seattle.
These include people born with bats that have become dangerous pathogens in humans, and another subgenus that causes a serious human lung disease that is transmitted by domediri camels, as well as a few other subgenres that cause colds. Cause common symptoms.
The team tested whether S2P6 could protect against SARS-CoV-2 by giving hamsters 24 hours before the Steam Helix antibody exposure. They found that this antibody reduced the viral load of SARS-CoV-2 by inhibiting the entry of the virus and enhancing the cellular immune response to additional antivirals and virus clearing.
In addition to pre-epidemic human samples, plasma studies were performed on people who had been vaccinated and recovered from those who had been vaccinated to see how often Stem Helix appeared to be exposed to antibodies.
The highest incidence was in people who recovered from Covid 19, then vaccinated later. Overall, however, the data from this study show that, when this happens, the response of plasma stem helix antibodies to SARS-CoV-2 is relatively low.

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