Scientists make embryo-like research models from human stem cells

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London: Scientists have used human embryonic stem cells to create an embryo-like research model to help them study some of the early stages of human development.
The model overcomes some ethical restrictions on using human embryos for research and will allow scientists to study a period of human development known as the “black box” period, which they say has never before been directly Has not been seen
“Our model is part of the human blueprint,” said Alfonso Martinez-Arius, a professor at the University of Cambridge, UK who co-led the project.
“It is exciting to see the processes of development that have hitherto been hidden from view – and from study.”
The hope, he said, is that understanding these processes can reveal the causes of human birth defects and diseases, and the development of tests for them in pregnant women.
The blueprint of an organism is produced through a process called “gastrulation”, which begins about two weeks in development in humans. Gastrulation is known as the ‘black box’ period of human development, as legal restrictions prohibit culture of human embryos in the laboratory beyond 14 years.
Experts not directly involved in the work – due to be published in the journal Nature on Thursday – said it was an important step towards deepening understanding of human life.
Teresa Rayon said, “This work connects to an ‘in vitro toolkit’ that scientists can now use to study the most unknown stages of human pregnancy – between 2 and 4 weeks, where women are normally pregnant.” Won’t know. ” Francis Crick Institute Specialist.
Previous embryonic-like models made from mouse stem cells have limited what they can tell scientists about human development.
For this work, Martinez-Arius’s team created gastuloids in a lab using human embryonic stem cells and treating them with chemical processes.
Gastuloids have no ability to develop into fully formed embryos. The researchers stated that they do not require brain cells or any tissue for implantation in the womb, meaning they will never be viable beyond the initial stage and therefore conform to ethical standards.

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