Scientists remove the possibility of coronovirus mutation, saying ‘Malaysia strain’ is not a cause for concern

Scientists remove the possibility of coronovirus mutation, saying ‘Malaysia strain’ is not a cause for concern

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Scientists say the mutant form of the novel coronovirus being “10 times more infectious” from Malaysia is not a concern for India because it is widely prevalent here and no more viral than the strain that originated in Wuhan Is not.
The country’s director general of health said in a Facebook post this week that the virus was discovered from a cluster in D614G strain Malaysia, including a restaurant owner returning from India.
He claims that it was “found to be 10 times more contagious and easily spread by an individual super spreader” created a flutter but scientists here dispelled the apprehensions and said there was nothing to worry about.
According to virologist Upasana Ray, mutations have only been reported in Malaysia, but are not new to the world.
A senior scientist at Kolkata’s CSIR-Indian Institute of Chemical Biology told PTI, “We saw it happening in April and it has come to dominate many countries. It is new to Malaysia, but it is not a new change.” ”
Although some reports have claimed that the mutation is capable of increasing the infectivity of the virus, it is not well established and does not even indicate the disease to be more viral or harmful. Ray stated that even a highly contagious and transmitted variant of the virus may actually have a reduced ability to cause disease in humans.
In July, a study in the journal Cell by scientists including Bette Korber from Los Alamos National Laboratory in the US noted that a variant of the novel coronavirus called ‘core D614G’ could infect more lab-grown cells than other strains is.
The study states that this mutant – in which one molecule acidaspartic acid ‘(denoted as D) is replaced by another building block buildingglycine’ (G) – is soon to become a major stressor worldwide. Was taken as it first appeared, and grew more rapidly in laboratory-developed cells. This mutation is a part of the spike protein that the novel coronavirus virus uses to enter host cells.
The strain with the D614G mutation, dubbed the ‘G clade’, became widely prevalent in India by April as well, with Kumar Somasundaram, professor of microbiology and cell biology at the Indian Institute of Science (IISc) Bangalore agreeing.
TheG Clad? Or the variant, currently makes up about 70–75 percent of cases in India, he told PTI.
In June, Somasundaram’s team published a study in the journal Science, which analyzed hundreds of virus samples in India.
“Back in April, if 100 patient samples were analyzed in India, 40–50 percent of them had the G clade virus. If you look at the ones analyzed in June, about 95 percent are G clad. If you Combining all that, the samples that have been analyzed for months, the G clade makes up 70–75 percent of cases in India, ”he explained.
While the virus’s origin was the D clade of the “wild type” virus from the first epicenter in Wuhan, China, most outbreaks in India started with infected people returning from Europe with the G clade.
“In February – March, the viruses detected in Indian patients came mainly from Europe, and to a lesser extent from the Middle East and Oceania. And yet, the G clad virus was cultivated in Europe. And then it The tension was beginning to increase. More and more prevalent in India, ”Somasundaram said.
Unlike many other parts of the world, such as the US, where other currents were initially present, the IISc microbiologist stated that the outbreak of G in India was even more prevalent at the onset of the outbreak.
“Because this virus can grow rapidly, it was able to take advantage over other types, and has started taking on other strains almost entirely. This is also true in a worldwide scenario where it dominates other strains. Happening, “he said.
Somasundaram said, “Over a period of time, G Clade has taken advantage of its ability to spread and has captured about 95 percent of infected patients.”
However, they reported that there is no difference in strain compared to wild-type virus or other strains in terms of COVID-19 disease outcome.
“The G clade virus has no distinct effect on disease severity or outcome. In this way it is no different from the wild type.” Somasundaram said.
While studies, such as Kober and his team, have demonstrated that the G clade virus has the potential to infect more laboratory-grown cells than other strains, some virologists argue that it still increased in humans There may not be evidence of permeability.
Scientists, including Angela Rasmussen of Columbia Mailman School of Public Health in the US, noted in a recently published comment in the journal Cell that laboratory tests could demonstrate the virus’ ability to infect a cell in culture. ” It is unclear what is in it that means the ability to productively transmit to a new host “.
Rasmussen and his colleagues stated, “These assays do not account for the effects of other viral or host proteins and the parade of biochemical host – pathogen interactions that support infection and transmission.”
According to Somasundaram, mutations in the G clade virus spike protein may have no effect for vaccine development.
“Initially, it was alleged that a vaccine developed against the wild-type virus might not work against the mutant form. But there could be no difference in terms of how the immune system recognizes the virus.”
Somasundaram reported, “Mutant S proteins can also be neutralized by a vaccine developed against a virus type virus.”
Rasmussen’s team also noted this.
He stated that antibodies resulting from natural infection with the D or G clad virus can cross-neutralize, suggesting that “D614G mutations are unlikely to have a major impact on the efficacy of vaccines currently in the pipeline”.
Ray stated that a safe strategy for developing vaccines could be to find targets in other regions of spike proteins that have not undergone mutations.
He added, “Spike proteins have other regions that are more stable and thus should be targeted. Monitoring of this mutation and intensive research on this mutation is needed.”

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