Scientists say coronovirus can infect the heart cells of Kovid-19 patients

Scientists say coronovirus can infect the heart cells of Kovid-19 patients

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LOS ANGELES: Researchers, including people of Indian origin, have shown that novel coronovirus can infect lab-enhanced cardiac muscle cells, indicating that the virus is a direct heart infection in Kovid-19 patients. May cause.
The study, published in the journal Cell Reports Medicine, was based on experiments conducted in laboratory-developed heart muscle cells that originated from unspecified human stem cells.
Arun Sharma, co-author of the Cedar-Sinai board study, said, “We have not only revealed that these stem cell-derived heart cells are susceptible to infection by novel coronaviruses, but that the virus has been found in heart muscle cells Can also be sharply divided. ” Governors Regenerative Medicine Institute in America.
“More important, infected heart cells showed a change in their ability to beat after 72 hours of infection,” Sharma said.
Although many Kovid-19 patients experience heart problems, scientists said the reasons for these symptoms are not entirely clear.
He said that all have been implicated as a result of pre-existing cardiac conditions, or inflammation and infection from lack of oxygen.
According to scientists, only limited evidence is available that the novel coronavirus, SARS-CoV-2, directly infects individual muscle cells of the heart.
The current study showed that SARS-CoV-2 can infect heart cells derived from human stem cells and alter how genes in these cells helped to make proteins.
Based on this observation, scientists confirmed that human heart cells could be actively infected by the virus to activate innate cellular “defense mechanisms” in an effort to help clean up the virus.
Citing the study’s limitations, he said that these findings are not a perfect replica of what is happening in the human body because the research was done in laboratory-developed heart cells.
However, this knowledge may help investigators use stem cell-derived heart cells as a screening platform to identify new antiviral compounds that can reduce cardiac viral infections, study co-author Clive Svendson Believes.
“Viral epidemics are defined primarily by respiratory symptoms, but there are also cardiac failures, including arrhythmia, heart failure, and viral myocarditis,” said Svensen, director of the Regenerative Medicine Institute.
“While this may be the result of large-scale inflammation in response to the virus, our data suggest that the virus in Kovid-19 may also directly affect the heart,” Svendson said.
Scientists also found that treatment with an antibody protein could lock on the human cell surface receptor ACE2 – a known SARS-CoV-2 ‘gateway’ in cells.
According to the researchers, antibody treatment was able to blunt viral replication on laboratory-grown heart cells, suggesting that the ACE2 receptor may be used by the virus to enter human heart muscle cells.
“By blocking the ACE2 protein with an antibody, the virus is not able to readily bind the ACE2 protein, and thus cannot easily enter the cell,” Sharma said.
“This not only helps us understand how this virus functions, but also explains the therapeutic approach that it can be used as a potential treatment for SARS-CoV-2 infection,” he said.
In the study, researchers also used human-induced pluripotent stem cells, or iPSS, a type of unspecified cells grown in the laboratory from a person’s blood or skin cells.
He said that IPSCs can make any type of cell found in the body, carrying the genetic material of each person.
According to scientists, tissue-specific cells made in this way are used for research, and for creating and testing potential disease treatments.
“It is plausible that direct infection of heart muscle cells can contribute to Kovid-related heart disease,” said Eduardo Marban, executive director of the Smit Heart Institute in the US, and co-authored the study.
“This important experimental system can be useful for understanding differences in disease processes of related coronaviral pathogens, SARS and MERS,” said Vaithilingaraja Arumugaswamy, another co-author of the study from the University of California Los Angeles in the US.

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