Scientists say that will help understand bat immune system

Scientists say that will help understand bat immune system

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New York: Novel coronoviruses such as the bats’ ability to tolerate the virus may stem from its ability to control inflammation, according to a review of studies that say understanding the immune system of flying mammals for human vaping against covids May provide new drug targets. -19.
Including researchers at the University of Rochester in the US, said bats are the ancestral hosts of many deadly viruses affecting humans, such as Ebola, rabies and the novel coronavirus, SARS-CoV-2, flying mammals themselves tolerate these pathogens without effect. K.
“Although humans experience adverse symptoms when suffering from these pathogens, bats are remarkably capable of tolerating the virus, and, moreover, live longer than similarly sized mammals,” he said. Mentioned in a statement.
In review research published in the Journal of Cell Metabolism, scientists assessed how bats’ natural ability to control inflammation may contribute to their longevity and tendency to fight against diseases.
University of Rochester co-author Vera Gorbunova said, “With Kovid-19, inflammation goes haywire, and it can be the inflammatory response that is killing the patient, even more than the virus.”
“The human immune system works like this – once we become infected, our body rings an alarm and we develop fever and inflammation,” Gorberova explained.
He said that the goal of this immune system response in humans is to kill the virus and fight infection, but added that it can also be a harmful reaction because patients’ bodies are exposed to danger.
But unlike humans, scientists said that bats have specific mechanisms that reduce virus replication in their bodies, and also reduce their immune response to the virus.
As a result, he stated that bats have a beneficial balance with their immune systems that control bats, and that a strong inflammatory response is not increasing at the same time.
According to the researchers, one of the factors of this ability may be driven by their flight.
Bats, the only mammals that can fly, require that they adapt to rapid increases in body temperature, sudden increases in metabolism, and molecular damage, scientists explained.
He said that these adaptations can also aid in disease resistance.
Another factor in the increased immunity in bats may be due to their environment, researchers said, where many species of flying mammals live in dense colonies, and hang together on cave roofs or trees.
“The bats are constantly exposed to the virus. They always go out and bring something new to the cave or nest, and they move the virus because they live so close to each other,” Andrei Seluanov, another co-. Author The Study.
Because bats are constantly exposed to the virus, scientists believe that their immune systems are in a “permanent arms race with pathogens” – a pathogen will enter the organism, the immune system will develop a mechanism to counter the pathogens , The pathogen will develop again, and so on.
“Dealing with all these viruses can take the shape of bats’ immunity and longevity,” Gorbunova said.
Developing social habits, parallel to bats, we have not yet developed sophisticated mechanisms of bats as they combat viruses and spread rapidly, the scientists noted.
Gorbunova stated, “Kovid-19 has such a different pathogenesis in older people. Life is one of the most important factors between living and dying, and we need to treat aging as a whole process rather than treating individual symptoms.” Have to be treated, ā€¯Gorbunova said.
According to researchers studying the immune system of bats, human medicine can provide new targets for fighting diseases and aging.
Citing an example, he stated that bats have mutated or completely eliminated many genes involved in inflammation, adding that scientists can develop drugs to inhibit these genes in humans.
“If we want to stop inflammation, we want to live longer and avoid the deadly effects of diseases like Kovid-19,” Gorbunova said.
“One should not come in contact with any virus, but it is not practical. Secondly our immune system has to be controlled like a bat,” he said.


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