Studies show that blood tests can show early signs of severe Covid 19

Studies show that blood tests can show early signs of severe Covid 19

Washington: A recent study has found that a series of biomarkers, or biological signals linked to white blood cell activation and obesity, can predict severe outcomes in patients with COVID 19.
The results of the study were published in the journal Blood Advance.
When patients with COVD-19 arrive in the emergency room, there are relatively few ways for doctors to predict which of them are more likely to become seriously ill and Requires intensive care and is more likely to enjoy immediate recovery. However, this study focuses on biomarkers that can help predict severe outcomes in Covid 19 patients.
“Patients with high levels of these markers were more likely to need care in an intensive care unit, ventilation, or death due to their covid 19,” said Dr. Hyung Chen, lead author. , Said an associate professor of medicine at Cardiovascular. Director of Medicine and Pathology and Interpreter Research at the Yale Pulmonary Vascular Disease Program.
Earlier, some laboratory studies identified possible indications for acute covid-19, including a measure of D-dimer, a measure of blood clotting, and protein levels that are part of the body’s inflammatory response. Are issued as. So far, however, no laboratory marker has been able to predict which patients with Covid-19 will eventually become seriously ill before showing signs and symptoms of a serious illness.
For the new study, Yale researchers used proteomic profiling – screens for multiple proteins in the blood – to analyze samples taken from 100 patients who experienced varying levels of COVID-19 intensity. In all cases, patients’ blood samples were collected on the first day of admission. The researchers analyzed clinical data for more than 3,000 additional patients within the Yale New Haven Hospital system.
They found that five proteins (Resisten, Lipoclin-2, HGF, IL-8, and G-CSF), which are a type of white blood cell, were increased in 19 patients who later became acute. Got sick Many of these proteins have previously been linked to obesity, but not to covid-19 or viral diseases.
In particular, advanced neutrophil biomarkers become apparent to patients who experience more severe symptoms before these symptoms appear. All patients with COVID-19 who were admitted or transferred to the ICU had an increase in neutrophil activation markers, while these biomarkers remained low for patients who had never had a serious illness. Happened None of the patients below the neutrophil biomarker level died.
“This is one of the first demonstrations that a set of biomarkers in the blood of code patients can predict admission to the ICU before such patients become seriously ill,” said study author Dr. Alfred Lee. , Associate Professor of Medicine in Hematology, Director of the Yale Medical Oncology Hematology Fellowship Program, and a member of the Yale Cancer Center.
Early knowledge of these indications could significantly improve patients’ treatment, researchers say.
“If the diagnostic test [for these biomarkers] Choice can be ordered, which gives us a better idea of ​​who is more likely to become seriously ill and who will benefit from the high level of care and attention to their treatment. Affects the immune system from the time of hospitalization.
“Many of these drugs have potential side effects, and this test can help identify patients who will benefit the most,” Chen added.
The researchers said that the study also emphasized the link between COVID-19 and obesity. The Centers for Disease Control and Prevention notes that obesity and severe obesity increase the risk of covid-19 severe disease. Obesity triples the risk of hospitalization with covid-19, and the level of body mass index is associated with the risk of death with covid-19.
Neutrophils are inflammatory cells, so it’s understandable that they would both be elevated in the context of obesity – including chronic, mild inflammation – and Covid 19, which in extreme cases causes hyper-inflammation, Lee said. Causes tissue damage and organ damage.
“There are also symptoms that can contribute to neutrophil thrombosis or blood clotting,” said Lee, another disturbing identifier of Coyote-19.
Researchers will expand their study into the relationship between biomarkers and covid-19 by looking at patients recovering from a serious illness.
“We hope that these results will encourage other groups to look at their patient populations,” Chun said, adding that they would need additional validation studies to develop diagnostic tests for these biomarkers. I will be helpful.
“The evolution of our findings really demonstrates the power of collaboration, which has emerged as a promising aspect of this devastating epidemic that we will continue to achieve stability for the benefit of patients,” Lee said.

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