Studies show that covid-19 patients have a higher risk of cardiac damage

Studies show that covid-19 patients have a higher risk of cardiac damage

WASHINGTON: About 50 percent of patients admitted to the hospital with severe Covid 19 symptoms show levels of a protein called troponin, which damages their hearts, a recent study found.
A magnetic resonance imaging (MRI) scan revealed the injury at least a month after it was released, according to a new study published today (Thursday) in the European Heart Journal.
Damage includes inflammation of the heart muscle (myocarditis), scarring or death of the heart tissue (infection), limited blood supply to the heart (ischemia) and a combination of all three.
The study of 148 patients at six acute London hospitals was the largest study ever to diagnose 19 patients who had increased levels of tryptophan, which could indicate a possible heart problem.
When the heart muscle is injured, tryptophan is released into the bloodstream. Elevated levels may occur when the artery is blocked or there is inflammation of the heart. Many hospitalized patients with covid-19 have increased levels of tryptophan during the critical phase of the disease when the body develops an exaggerated immune response to the infection. Elevated levels of tryptophan were elevated in all patients in this study who followed up with an MRI scan of the heart after discharge to understand the causes and extent of the damage.
Mariana Fontana, a professor of cardiology at University College London (UK), along with Dr Graham Cole, a cardiologist at Imperial College London, said: 19 Patients with the disease often experience pre-existing cardiovascular health problems, including diabetes, high blood pressure and obesity.
“However, during a CUV-19 infection, the heart can also be directly affected. How the heart can be damaged is difficult to uncover, but MRI scans of the heart can identify different patterns of injury, which gives us more accurate information. Be able to diagnose and target treatment more effectively, “Fontana added.
In the researchers’ investigation, 19 patients were discharged from six NHS London hospitals by June 2020: Royal Free London NHS Foundation Trust, Imperial College Healthcare NHS Trust, and University College London Hospital N.Y. HS Foundation Trust.
Patients with abnormal tryptophan levels were offered an MRI scan of the heart after discharge and compared with patients in the control group of patients who did not have code 19, as well as 40 healthy volunteers. Also
Professor Fontana said: “The patients who recovered from Covid 19 were very ill. All needed hospitalization and all had traponin elevation, with one in three on the ventilator in the intensive care unit.”
“We have found evidence of a high rate of heart muscle injury that can be seen on scans a month or two after discharge. While some of it may already be present, MRI scanning shows that some 19. Importantly, the extent of damage to the heart was variable, indicating that the heart is at risk for a variety of injuries. We found only a small amount of ongoing injury, we saw a heart injury that was present even when the heart’s pumping function was not impaired and it may not have been picked up by other techniques. Very serious. In some cases, there are concerns that the injury may increase the risk of future heart disease, but more work is needed to investigate. ”
The function of the left ventricle of the heart, the chamber responsible for pumping oxygenated blood to all parts of the body, was normal in 89% of 148 patients but a scar or lesion in the heart muscle was present in 80 patients (54%). Inflammation in the form of tissue scarring or injury in 39 patients (26%), ischemic heart disease, which includes infection or ischemia in 32 patients (22%), or in nine patients (6%) Has happened Twelve patients (8%) experience ongoing heart inflammation.
Professor Fontana said: “Heartburn and scar-related injury are more common in patients discharged from the hospital than in patients with elevated troponin in covid 19, but to a limited extent and with very little consequence of cardiac efficacy. Is.
“These findings give us two opportunities: firstly, to find ways to prevent injury in the first place, and from some of the patterns we’ve seen, blood clotting can play a role, for which we have potential There are treatments. Second, detection. As a result of injury during pregnancy, subjects can be identified who, over time, will benefit from drug-specific adjuvant treatment to protect the function of the heart. ”
The results of the study were limited to the nature of patient selection and included only those who survived a corona virus infection that required hospitalization.
“The patients in this study had a severe case of covid-19 and our results do not say anything about what happens to covid with non-hospitalized patients or hospitalized patients.” “Identify high outcomes or possible ways to identify patients,” said Professor Fontana. “Reducing the risk and suggesting possible strategies that could improve outcomes. More work is needed, and cardiovascular.” MRI scans have shown how useful it is in the investigation of patients with elevated troponin, “Professor Fontana concluded.

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