Studies show that Covid 19 virus is highly highly adapted to infect human cells.

Studies show that Covid 19 virus is highly highly adapted to infect human cells.

MELBOURNE: The SARD-2 virus, which causes Quard 19, is more likely to infect human cells than ideally son or penguin cells, according to the study, which raises questions about the origin of the virus.
Researchers at the University of Flinders and the University of La Trobe in Australia used high-performance computer modeling in the form of the SARS-CoV-2 virus at the beginning of the epidemic to predict the potential for infection in humans and 12 domestic and exotic animals. can go.
The study, published in the journal Scientific Reports on Thursday, aims to help identify any intermediate animals that have been linked to the spread of the BAT virus in humans.
The researchers used genomic data from 12 animal species to develop computer models of key ACE2 protein receptors for each animal.
These models were then used to calculate the binding strength of the SARS-CoV-2 spike protein to each species of ACE2, which acts as a receptor for SARS-CoV-2 and thereby affects the cell. Lets happen
The results show that SARS-CoV-2, which binds ACE2 to human cells, is more strongly involved in some of the more experienced animal species, including bats and penguins.
The researchers explained that if the animal tested was the origin of a species, it would generally be expected to be the most binding of the virus.
Humans showed the strongest binding of the spike, according to Professor David Winkler of the University of La Trobe, who was highly susceptible to the virus, but wondered if an animal was the primary source of infection in humans. The Troub University professor said.
Winkler said computer modeling showed that the virus’s ability to bind to the ACE2 protein was limited in its ability to bind to cells.
Researchers argue that this could lead to the virus being transmitted directly from bats to humans.
Nikolai Petrovsky, a professor at the University of Flanders, said that if the virus had a natural source, it could have been transmitted to humans only through a kind of intermediary, which is not yet known.
The team’s computer modeling shows that the SARS-Co-2 virus is also relatively strongly bound to ACE2, which is found in parts of Southeast Asia.
Winkler said the pangolin showed the most growing strength of all the animals seen in the study, which was significantly higher than that of bats, monkeys and snakes.
The researchers said that some scientists had wrongly suggested at the onset of the epidemic that they had found stork-co-2 in pangolins.
Petrovsky said it was a misunderstanding and that the claim was quickly withdrawn because he described the pangolin coronavirus as having less than 90% genetic resemblance to the Sars Covey 2 and therefore his ancestors. Can’t be
This study and others have shown that the specific part of the pangolin coronavirus spike protein that binds ACE2 was similar to the SARS-Covey-2 spike protein.
According to the researchers, the sharing of almost identical spike proteins by which the virus enters the cells almost certainly explains why SARS-CO-2 binds the penguin ACE2 so well, according to the researchers.
“Overall, aside from the results of the complex penguin ACE2, our study shows that the Kovid-19 virus was very well adapted to infect humans,” Petrovsky said.
The study also found that some pets, such as cats, dogs and cows, are also at risk for SARS-CoV-2 infection.
He said there are currently two important explanations for the very important and open question of how the virus infected humans.
According to the researchers, the virus has entered humans from bats through a medium-sized animal, yet they have not been detected.
However, he could not be ruled out as he was accidentally released from a virology lab, he said.
The researchers added that a thorough scientific, evidence-based investigation is needed to determine which of these explanations is correct.

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