Studies show that the host mutations in the Covid 19 virus appear differently.

Studies show that the host mutations in the Covid 19 virus appear differently.

New Delhi: Changes in the genome of the SARS-CoV-2 virus in an infected person appear to be mutations at the population level, according to a study by researchers. There will be more benefits of “viral covid strain.
The researchers said that detecting changes in the virus within a host of individuals and populations could provide an important pathway to viral sites that are conducive or harmful to the survival of SARS-CoV-2 that cause code 19. Are formed.
The team behind the recent research included researchers from the National Center for Disease Control and CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), as well as the Institute of Life Sciences, Academy of Sciences and Innovation in Bhubaneswar. Research in Ghaziabad, CSIR-Center for Cellular and Molecular Biology (CSIR-CCMB) in Hyderabad and Indian Institute of Technology, Jodhpur.
Reacting to the results of the study, virologist Apasna Ray explained that the appearance of viral variants depends on its successful reproduction in the host.
“Mutation is a very common phenomenon in the life cycle of any virus. As a virus passes through the replica and grows inside the host cell, it mutates into smaller nucleotides.
“As the virus spreads more and more, there are plenty of opportunities for such changes to accumulate within the host, and thus differentiated,” said Ray, who did not participate in the study.
In a yet-to-be-published study published in the pre-print repository BioRxiv on July 27, researchers analyzed samples from 19 diagnosed patients at two different epidemics.
In the first phase of the study, the team analyzed the latest 1,347 samples collected from various sub-populations of China, Germany, Malaysia, the United Kingdom, the United States and India as of June 2020 to determine genome-wide intra-host single nucleotide mutations in SARS. iSNV) map can be found. -CoV-2 affected population.
A single nucleotide mutation (SNV) is an alternative to a nucleotide – the basic building block of the genetic material of a virus.
According to Ray, there are variations within the iSNV host. He added that these changes ultimately appear at the population level or not.
“For an intrahost SNV to survive, such a species must be able to multiply and spread and therefore establish itself,” the scientist said.
The researchers observed 18,146 ISNV sites spread across the viral genome, including those that described the B1 and B.6 lineages.
The alpha variant, first identified in the UK, the beta variant was first found in South Africa and the delta variant, first reported from India, belongs to this lineage of SARS-CoV-2.
Interestingly, 41% of all unique ISNVs identified in these samples were found in one or more samples collected in GISAID as SINV as of September 30, 2020, which is 80 as of June 30, 2021. Percent. The study noted.
GISAID is a global science initiative and primary resource that provides open access to the genomic data of the influenza virus and the corona virus responsible for the Covid 19 epidemic.
In the second phase of the study, the authors analyzed 1,798 samples compiled in India between November 2020 and May 2021.
They found evidence that ISNVs may appear in SNVs in populations over time.
“In these samples, iSNVs can be recorded to be present in the majority of the population of Delta (B.1.617.2) and KAPA (B.1.617.1) from their designation as SNVs by February 2021. Explains the first lineage, “said the researchers.
“These findings highlight the importance of recording ISNVs as genomic surveillance programs are expanded to enable more accurate models for viral epidemics,” he said.
The authors observed ISNV in 87% of spike protein sites – which the virus uses to infect and infect human cells – which have recently been reported to provide antibody resistance.
Current vaccines are against the spike protein of the SARS-COV-2 virus.
“These mutations can have major implications for vaccine reactions because they can alter the immune system,” the authors said.
Immunity The vaccine has the ability to provoke an immune response in the body.
Ray added, “The study provides important insights into whether or not the remnants are conducive to the survival of the virus and thus could help engineer the next generation of treatments that address these mutating proteins.” Target. ”

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