Studies show that women taking beta blockers for high blood pressure may have a higher risk of heart failure

Studies show that women taking beta blockers for high blood pressure may have a higher risk of heart failure

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Washington DC: According to new research, women taking beta-blockers for hypertension with a prior history of heart disease (CVD) have an approximately five percent higher risk of heart failure than men when they go to hospitals with acute coronary syndrome. it happens. The study was published in the journal ‘Hypertension’, an American Heart Association.
Beta-blockers are drugs that reduce high blood pressure and are prescribed to adults with high blood pressure, which is a major cause of CVD. In this study, researchers analyzed the effects of beta-blockers on men and women with hypertension and history of CVD after presenting with acute coronary syndrome.
Following the occurrence of heart failure it was recorded to determine whether the drug produced different results based on biological differences.
“Previous research on the effects of beta-blockers included most of the participants who were male, so we tried to examine how sex / gender plays a role in patient outcomes,” Rafael Bugiardini, MD, University of Cardiology Professor Bologna and lead author of the study.
Bugiardini stated, “Women have historically been depicted in most clinical studies on hypertension. Future research is important to include equal division of male and female patients, which may shed light on disparities and actionable treatments.” Is, ā€¯Bugiardini said.
The study analyzed information from the International Survey of Acute Coronary Syndromes (ISACS) archives, ISACS-TC and EMMACE-3X clinical registries from October 2010 to July 2018.
The research included data from 13,764 adults from 12 European countries with high blood pressure and no prior history of CVD. Patients were classified by sex / gender and then divided into two groups: those taking beta-blockers and those who did not.
Researchers found that among participants taking beta-blockers:
1) the rate of heart failure was 4.6 percent higher in women than men when presented in hospital with acute coronary syndrome;
2) the mortality rate of both men and women with heart failure was nearly seven times that in patients with acute myocardial infarction and heart failure complications;
3) Women who had ST-segment myocardial infarction (STEMI) were 6.1 percent more likely than men with STEMI to have a severe form of heart attack in those with a heart attack.
4) The rate of heart failure was almost the same in men and women who did not take beta-blockers.
“What we found presents a convincing case for re-examining the use of beta-blocker therapy for women with hypertension. For women who have no history of heart disease and only hypertension, we feel Is that it is incredibly important for them to regulate them. Blood pressure through diet and exercise, “Bugiardini said.
The coronary artery is completely blocked and a large part of the heart muscle is unable to receive blood; And,
“It is possible that the risk of heart failure for women is due to interactions between hormone replacement therapy and beta-blockers, although this information was not collected or tested in our study. It and other potential factors may be more in-depth. Need to check. ”
Researchers noted some limitations. Since the study was observable, there may be some variation in results and additional data is required for confirmation. However, a randomized controlled trial of beta-blocker therapy in hypertensive patients cannot be considered ethical because it will not be designed to confirm the risk and benefit. The study was not involved in, nor for information about, time patients used previous treatments or doses of beta-blockers.
Through its signature, women’s initiative, Go Red for Women, the American Heart Association has advocated increased representation of women in cardiovascular research studies for nearly two decades. Go for Women Research Red empowers women to contribute to health research.
The initiative has created a community of women scientists, researchers and medical and health professionals to raise awareness about women’s heart health by closing the gender disparity gap in research and clinical trials. In light of the Kovid-19 epidemic, Research Goals Red expanded its reach. Access and impact through a Kovid-19 survey. The survey assesses the top concerns women have regarding their health, social, economic and emotional impact on their lives.


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