Studies show that working night shifts can increase the risk of cancer

Studies show that working night shifts can increase the risk of cancer

Washington: A novel study led by a team of researchers from Washington State University has shed light on why night shift workers may have a higher risk of certain types of cancer than those who work during the day. Is.
The results show that night shifts disrupt the natural 24-hour rhythm in the activity of certain cancer-related genes, increasing the risk of DNA damage to night shift workers and the body’s DNA. The repair method is also misused to deal with this damage.
Published online in the Journal of Pineal Research, the study involved a controlled laboratory experiment using healthy volunteers who were on night shift or day shift schedules.
Although more research is needed, these findings could one day be used to help prevent and treat cancer in night shift workers.
One such associate professor, Shubhan Gadamidhi, said, “There is a lot of evidence that night shift workers are more prone to cancer, which is why the work of the World Health Organization’s International Night Shift Agency Was forced to classify as a potential carcinogen. ” First with the WSU College of Pharmacy and Pharmaceutical Sciences, and now with the Department of Biological Sciences at North Carolina State University and the Center for Human Health and the Environment.
“However, it is not clear why night shift work increases the risk of cancer, which is what our research seeks to address.”
As part of a partnership between the WSU Sleep and Performance Research Center and the U.S. Department of Energy’s Pacific National Waste National Laboratory (PNNL), PDNL’s Worked with bioinformatics experts, the body’s internal mechanisms that keep us on the cycle 24 hours a day and night.
Although the brain has a central biological clock, almost every cell in the body has its own built-in clock. This cellular clock contains genes known as clock genes that have rhythms in their expression, meaning that their levels of activity vary during the day or night.
The researchers speculated that the expression of cancer-related genes may also be rhythmic, and that night shift work may affect the rhythm of these genes.
To test this, they experimented with an artificial shiftwork in which 14 participants spent seven days in a sleep laboratory at WSU Health Sciences Spokane. Half of them completed a three-day artificial night shift schedule, while the rest were on a day shift schedule for half a day.
After completing their simulation shifts, all participants were placed in a permanent routine protocol used to study the biologically generated human locks that are not free from any external influences.
As part of the protocol, they were kept awake for 24 hours in a half-hour posture under constant light exposure and room temperature, and were given the same breakfast every hour. A blood sample was prepared every three hours.
Analysis of white blood cells from blood samples showed that the rhythms of many cancer-related genes were different from those in the night shift to the day shift. In particular, DNA repair genes that showed different rhythms during the day shift lost their momentum during the night shift.
The researchers then looked at the effects of changes in the expression of cancer-related genes. They found that white blood cells were isolated from the blood of night shift participants, which showed more evidence of DNA damage than D shift participants.
And what’s more, when the researchers exposed the isolated blood cells to ionizing radiation at two different times of the day, they found that the cells circulating in the evening had a night shift state rather than a day shift state. Showed an increase in NA losses.
This meant that the white blood cells of the night shift participants had a higher risk of external damage from radiation, DNA damage and cancer.
“Together, these findings show that night shift schedules reduce the time it takes for cancer-related genes to express themselves in a way that reduces the effectiveness of the body’s DNA restoration process when they Is required. ” A computational scientist with the Biological Sciences Division of the Pacific National Laboratory.
The researchers’ next step is to conduct the same experiment with real-world shift workers who have been working in day or night shifts for many years to determine if night workers have extra time off. Damages the NA, which can ultimately increase the risk of cancer
If what happens in real-world shift workers is consistent with current results, this work could ultimately be used to develop prevention strategies and drugs that address the mismanagement of the DNA restoration process. Can remove
It can also be the basis for a strategy to improve the timing of cancer therapy so that treatment is given only when the reactions are highest and the side effects are minimal. , A procedure called chrono therapy that will require the night locks to be properly connected to the internal locks.
“Night shift workers face significant health risks, ranging from the increased risk of metabolic and cardiovascular disease,” said Hans Van Dongen, a senior co-author and professor and director of the WSU Elson S. Floyd College of Medicine. It can lead to mental health problems and even cancer. ” WSU Sleep and Performance Research Center.
“Now is the time for us to find solutions to diagnose and treat this poor group of essential workers so that the medical community can address the unique health challenges.”

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