Antibodies against novel coronaviruses may “quickly disappear” after recovery, a new study said that more than 250 Kovid-19 patients were evaluated up to five months after infection.
The study, published in the journal Science Immunology, analyzed 983 blood plasma samples collected from 79 hospitalized Kovid-19 patients and 175 outpatient and asymptomatic people infected with SARS-CoV-2 virus. . According to scientists, including Katharina Röltgen from Stanford University in the US, IgG antibodies are likely to persist for a long time, but have also seen a slow decline in critically ill patients that increase very strong early immune responses.
Based on the findings, the researchers stated that the levels of different types of antibodies that neutralize coronaviruses “begin to decrease in patients after approximately the first month of symptoms.” They found a higher proportion of antibodies that react to the viral spike protein complex in patients with mild disease than in critically ill patients.
Scientists wrote in the study, “The decline in antibody titers is most pronounced in individuals who have asymptomatic infection or mild disease, who produce low levels of antibodies at the peak of their reactions.” They believe the findings may raise important questions about the reliability of seroprevalence studies, as rapid declines in antibody levels in people may be underestimated by how many people were infected in previously given populations Can occur.
“The decrease in antibodies after infection also raises the question of how long-term antibodies are made by vaccination, and will require a steady increase to maintain safety”, the scientists said.
(This story has been published from a wire agency feed without textual modifications. Only the title has been changed.)
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