The study looks for a more reliable high-speed test for Covid 19

The study looks for a more reliable high-speed test for Covid 19

WASHINGTON: In a recent study, researchers at the University of Maryland School of Medicine (UMSOM) developed two rapid diagnostic tests for Covid 19 that are as accurate as the standard gold tests currently used in laboratories. Are
Unlike standard gold tests, which extract RNA and use it to propagate the virus’s DNA, these new tests can detect the presence of the virus in less than five minutes using a variety of methods. Are The results were published in the journal Nature Protocol.
One test is the Covid-19 molecular diagnostic test, called antisense, which uses electrochemical sensing to detect the presence of viruses. When the virus is present, the second uses a simple test of gold nanoparticles to detect discoloration. Both tests were developed by Dipenjan Pan, PhD, Professor of Diagnostic Radiology and Nuclear. Medicine And Pediatrics at UMSOM, and its research team. Dr. Penn has a joint meeting at the University of Maryland at Baltimore County (UMBC).
“These tests detect the presence of the virus within 5 to 10 minutes and rely on simple procedures that can be given very little lab training,” said Dr. Pan. They don’t need to extract the virus’s RNA – which is complicated and time consuming.
They are currently more reliable than high-speed antigen tests on the market, which only detect viruses in people with significantly higher viral levels. “These two new tests are highly sensitive and can detect the presence of viruses, even those with low levels of the virus,” said Dr. Pan.
Dr. Penn’s team included UMSOM Research Fellow Maha Alfif, UMSOM Research Associate Parsksit Moitra, PhD, and UMBC Research Fellow Ketan Dighe.
Last month, the U.S. Food and Drug Administration (FDA) registered Dr. Penn’s laboratory as an approved laboratory development site for antisense testing. The move will pave the way for Dr. Penn’s laboratory to launch tests at the university in research settings, as it progresses.
In February, RNA Diagnosis Inc. (RNADD) obtained special global licenses from UMB and UMBC to commercialize the test. Dr. Penn serves as an unpaid scientific consultant at the company.
This test detects the virus in a bush sample using an advanced technology called electrochemical sensing. It uses a unique dual-dimensional molecular detection approach to integrate electrochemical sensing for rapid detection of the SARS-CO2 virus.
“The final prototype is like a glucometer, which diabetics use at home to measure their blood glucose levels,” said Dr. Penn, “and it’s just as easy for people to do it themselves.”
Dr. Penn and his colleagues, in partnership with RNA Diagnosis Diagnosis, are launching a study of NBA basketball players in New York City to quickly compare the antisense test to the code test that N.Y. BA is using code to monitor infection in its players.
“We would like to see if our tests can yield more reliable results than existing platforms,” ​​he said. “The current antigen-based Rapid Covid test shows a reduction in infection by about 20 percent of the time and also a high rate of false positive results. Our antisense test is about 98 percent reliable, which p. It’s like a CR test. ”
Like the antisense test, the second rapid test does not require the use of any advanced laboratory techniques, such as the one commonly used to extract RNA for analysis. When the virus is present, it uses a simple probe containing plasmonic gold nanoparticles to detect color change. In April, Dr. Penn and colleagues published a step-by-step protocol in the journal Nature Protocols, explaining how nano-amplified chlorometric tests work and how they can be used.
Once a nasal swab or saliva sample is found in the patient, the nucleic acids (pieces of genetic material) in the sample are amplified through a simple process that takes about 10 minutes. The test uses a highly specific molecule attached to gold nanoparticles to detect a particular protein. This protein is part of a genetic sequence that is unique to the novel coronavirus. When biosensors are linked to the gene chain of the virus, gold nanoparticles respond by changing the liquid reagent from purple to blue.
UM Baltimore, executive vice presidents of medical affairs, and John Z., said, “Innovations in the CUVID-19 test are incredibly important as the epidemic in this country continues to decline.” And Akiko’s. Bowers Distinguished Professor and Dean, University of Maryland University of Medicine. “Because we monitor infections in the underprivileged segments of our population and reduce the likelihood of new variants spreading, it will require inexpensive rapid testing to ensure that we maintain a low rate of infection.” ۔ ”

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